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Papers of the Week


Papers: 4 May 2019 - 10 May 2019


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019 May 03


J Headache Pain


20


1

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy.

Authors

Labastida-Ramírez A, Rubio-Beltrán E, Haanes KA, de Vries R, Dammers R, Bogers AJJC, van den Bogaerdt A, Daugherty BL, Danser AHJ, Villalón CM, Maassen Van Den Brink A
J Headache Pain. 2019 May 03; 20(1):47.
PMID: 31053059.

Abstract

Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreover, rat neurogenic dural vasodilatation was used to explore their antimigraine mechanism of action.