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Papers of the Week
Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking.
Abstract
Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these antibodies prevent CGRP signaling through CGRP receptors have not been demonstrated.