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Papers of the Week


2019 Mar 06


Neuron


101


5

The Two Sides of Na1.7: Painful and Painless Channelopathies.

Authors

Waxman SG, Dib-Hajj SD
Neuron. 2019 Mar 06; 101(5):765-767.
PMID: 30844393.

Abstract

Sodium channel Na1.7 is a major target in pain research, largely because of genetic validation. In this issue of Neuron, McDermott et al. (2019) now present a comprehensive assessment of congenital pain insensitivity due to Na1.7 loss of function. This work and studies on Na1.7 gain of function raise important questions about how channelopathies produce disease.