I am a
Home I AM A Search Login

Papers of the Week


Papers: 23 Mar 2019 - 29 Mar 2019


Animal Studies, Pharmacology/Drug Development


2019 Jun


Br J Anaesth


122


6

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.

Authors

Kiguchi N, Ding H, Cami-Kobeci G, Sukhtankar DD, Czoty PW, DeLoid HB, Hsu F-C, Toll L, Husbands SM, Ko M-C
Br J Anaesth. 2019 Jun; 122(6):e146-e156.
PMID: 30916003.

Abstract

The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptors. BU10038 is a recently identified bifunctional MOP/NOP partial agonist. The aim of this study was to determine the functional profile of systemic or spinal delivery of BU10038 in primates after acute and chronic administration.