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Papers of the Week


Papers: 23 Mar 2019 - 29 Mar 2019


Human Studies, Pharmacology/Drug Development


2020 Apr 01


Pain Med


21


4

Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers.

Authors

Pickering G, Creveaux I, Macian N, Pereira B
Pain Med. 2020 Apr 01; 21(4):661-669.
PMID: 30908574.

Abstract

The influence of the genetic polymorphism of enzymes and receptors involved in paracetamol metabolism and mechanism of action has not been investigated. This trial in healthy volunteers investigated the link between paracetamol pain relief and the genetic polymorphism of 23 enzymes and receptors.