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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / ROS/TRPA1/CGRP signaling mediates cortical spreading depression.

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Papers: 2 Mar 2019 - 8 Mar 2019


Animal Studies

PAIN TYPE:
Migraine/Headache


2019 Mar 06


J Headache Pain


http://www.ncbi.nlm.nih.gov/pubmed/30841847?dopt=Abstract


20


1

ROS/TRPA1/CGRP signaling mediates cortical spreading depression.

Authors

ROS/TRPA1/CGRP signaling mediates cortical spreading depression.
Jiang L, Ma D, Grubb BD, Wang M
J Headache Pain. 2019 Mar 06; 20(1):25.
PMID: 30841847.

Abstract

The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in migraine by investigating the role of TRPA1 in cortical spreading depression (CSD) in vivo and exploring how reactive oxygen species (ROS)/TRPA1/CGRP interplay in regulating cortical susceptibility to CSD.
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