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Papers of the Week


Papers: 23 Feb 2019 - 1 Mar 2019


Animal Studies


2019


J Pain Res


12

Characterization of novel lnc RNAs in the spinal cord of rats with lumbar disc herniation.

Authors

Wang Q, Ai H, Liu J, Xu M, Zhou Z, Qian C, Xie Y, Yan J
J Pain Res. 2019; 12:501-512.
PMID: 30787629.

Abstract

Radicular pain, caused by a lesion or autologous nucleus pulposus (NP) implantation, is associated with alteration in gene expression of the pain-signaling pathways. lncRNAs have been shown to play critical roles in neuropathic pain. However, the mechanistic function of lncRNAs in lumbar disc herniation (LDH) remains largely unknown. Identifying different lncRNA expression under sham and NP-implantation conditions in the spinal cord is important for understanding the molecular mechanisms of radicular pain.