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Papers of the Week


Papers: 16 Feb 2019 - 22 Feb 2019


Animal Studies, Pharmacology/Drug Development


2019


J Pain Res


12

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.

Authors

Liu Y-D, Wang Z-B, Han G, Jin L, Zhao P
J Pain Res. 2019; 12:443-451.
PMID: 30774414.

Abstract

Our previous study suggested that HBO treatment attenuated neuropathic pain by inhibiting mTOR to induce autophagy in SNL neuropathic pain model. The aim of this study was to evaluate the role of AKT/TSC2/mTOR pathway in SNL and autophagy and determine whether HBO treatment could relieve neuropathic pain via modulating AKT/TSC2/mTOR pathway.