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Papers of the Week
Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
Abstract
Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia suggested the novel molecular candidate for generation of migraine pain. However, the contribution of Piezo channels in migraine pathology was not tested yet. Therefore, in this study, we explored a potential involvement of Piezo channels in peripheral trigeminal nociception implicated in generation of migraine pain.