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Papers of the Week


Papers: 12 Jan 2019 - 18 Jan 2019

PAIN TYPE:
Migraine/Headache


2019 Jan 16


Neuron


101


2

A TREK to Translate Genetics to Mechanisms of Migraine.

Authors

Hill RZ, Bautista DM
Neuron. 2019 Jan 16; 101(2):193-195.
PMID: 30653930.

Abstract

In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents.