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Comments
Howard Fields, University of California San Francisco
This is an excellent paper
This is an excellent paper investigating the analgesic effect of sucrose consumption under different conditions. The authors are able to demonstrate a robust and reproducible effect in adult male and female rats. It is of interest that this analgesic effect persists in a chronic pain state. It is not blocked by the opioid antagonist naloxone but is blocked by the CB1 partial agonist rimonabant, similar to the non-opioid form of placebo analgesia. The paper is well written and the bibliography contains many useful references.