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Papers of the Week


Papers: 5 Jan 2019 - 11 Jan 2019


Animal Studies, Pharmacology/Drug Development


2019 Mar


Biochem Pharmacol


161

Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.

Authors

Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, Cygankiewicz AI, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J
Biochem Pharmacol. 2019 Mar; 161:37-51.
PMID: 30611738.

Abstract

Molecular basis of abdominal pain in IBD is not fully characterized. Serotonin (5-HT) increases visceral pain severity and contributes to exacerbation of inflammation. Moreover, it is well established that decreased anandamide (AEA) signaling in the gut increases visceral pain severity. The aim of this study was to investigate the interplay between 5-HT and endocannabinoid signaling in colitis.