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Gao X, Zhang D, Xu C, Li H, Caron KM, Frenette PS
International Association for the Study of Pain
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Washington, D.C. 20005-1020
The IASP Pain Research Forum is a publication of the International Association for the Study of Pain
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Hiroshi Ueda, Nagasaki University Graduate School of Biomedical Sciences
This study seems to be the
This study seems to provide the first clinical evidence to support basic research showing that initiation of neuropathic pain requires lysophosphatidic acid (LPA) receptor signaling (Inoue et al. 2004) and that LPA-induced astrocyte activation is involved in the maintenance of partial sciatic nerve injury-induced neuropathic pain (Ueda et al., 2018). It is also impressive that there is a very good relationship between amounts of 18:1-LPA and 18:1-LPC (a precursor or substrate for autotaxin, an LPA-producing enzyme), since there is a report that an LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in a peripheral neuropathic pain model (Ma et al., 2013). As there is a report that LPA1 receptor is involved in fibromyalgia-like pain induced by intermittent psychological stress/empathy (Ueda and Neyama, 2017), LPA measurement from fibromyalgia patients is expected in the future.