Check out this recent editor's pick:
All site content, except where otherwise noted, is licensed under a Creative Commons BY-NC-ND License. Additional permissions for appropriate reuse available on request.
International Association for the Study of Pain
1510 H Street N.W., Suite 600
Washington, D.C. 20005-1020
The IASP Pain Research Forum is a production of the International Association for the Study of Pain
All site content, except where otherwise noted, is licensed under a Creative Commons BY-NC-ND License. Additional permissions for appropriate reuse available on request.
Comments
Ru-Rong Ji, Duke University Medical Center
This is an interesting study
This is an interesting study with translational potential. The authors found increased levels of miR-30c-5p in the CSF and serum of patients with neuropathic pain, suggesting that this miRNA may serve as a biomarker for neuropathic pain. Importantly, miR-30c-5p promotes neuropathic pain in rodents by inhibiting the expression of TGF-β , an anti-inflammatory cytokine that can inhibit neuropathic pain. miR-30c-5p also regulates other target genes. Thus, targeting this miRNA may lead to side effects, especially after intraventricular injection as employed in this study.