research

How do we predict pediatric pain trajectories? Who recovers from pain and for whom does pain persist? These questions were the focus of Laura Simons’ closing keynote address, “Predicting…

Many studies have shown interactions between the peripheral nervous system and immune system. But a detailed understanding of interactions between neurons and lymph nodes, and why this communication may…

Understanding pain experienced in childhood is crucially important, as pediatric pain sets the stage for both pain and healthcare experiences into adulthood. Of the many influences on childhood pain,…

Add allergen detection and the allergic immune response to the growing list of biological functions made possible by interactions between the nervous system and the immune system, according to…

Pain isn’t just under the dominion of neurons: Glial cells, including microglia and astrocytes, have long been known to modulate pain sensitivity via interactions with neurons in both acute…

Editor’s note: Eight young pain researchers were recently selected to provide news articles and other content as part of PRF’s Correspondents program, which provides a science communications training experience.…

Dendritic spines – small protrusions from the dendrites of neurons – have been familiar to neuroscientists for more than a century, especially to those studying the neuronal mechanisms of…

Immune cell recruitment and activation after nerve injury contribute to neuropathic pain, and recent studies have aimed to identify the types of immune cells and neuroimmune interactions that play…

The pain field has seen its share of disappointment on the drug development front, to the point where the so-called “failure of translation” has become an unavoidable cliché. But…

The sodium channel Nav1.7 is a key regulator of the firing of nociceptive neurons, and mutations in this channel can result in pain conditions as well as insensitivity to…

The role of the amygdala in pain has been closely considered by pain researchers for decades. The results have been somewhat contradictory: Recent research has mostly found pronociceptive contributions…

Pain, including migraine pain, can be associated with sensory changes. It can also be an extremely unpleasant experience. But while the sensory characteristics of migraine pain have been examined…

Peripheral sensory neurons are classified based on characteristics such as anatomical structure, physiological responses to stimuli, and expression of gene markers. In a further attempt at classification, a new…

Everyone knows how unpleasant itch can be, and the relief that comes from scratching. But when it comes to the causes of itch, while acute itch is commonly associated…