News

Jun 13 2019
Spontaneous Firing in DRG Neurons From Patients With Neuropathic Pain
Two studies of human transcriptome also bolster evidence for sex differences
news Research
Jun 03 2019
Calcitonin Gene-Related Peptide Causes Migraine-Like Pain in Female But Not Male Rodents
Sexually dimorphic response to dural CGRP may explain why migraines are more prevalent in women
news Research
May 23 2019
Kappa Opioid System in Nucleus Accumbens Drives Pain-Induced Negative Affect
Rodent study reveals that disinhibition of dynorphin-containing neurons explains reduced motivation seen during inflammatory pain
news Drug Development | Research
May 06 2019
A Search for Blood Biomarkers of Pain
A recent study identifies a number of blood gene expression biomarkers that predict pain in psychiatric patients; findings also point to new treatment avenues
news Research

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22 Jun 2019 to 26 Jun 2019
Genoa, Italy
Registration Deadline:
22 Jun 2019

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Jun 18 2019
The 2019 PRF-NAPS Correspondents Blog
PRF Correspondents

Six early-career pain researchers are participating in the ...

Discussion
Jun 18 2019
Advice to Young Researchers: Follow Your Passion and Buckle Up Your Seatbelt for Successful Translational Pain Research—A Podcast With Stephen Waxman
Danielle Perro

Seven early-career pain researchers took part in the ...

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Recent Comments

Jun 03 2019
By: Howard Fields
About: Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. Published May 9, 2019 by the US Department of Health.
Because of the epidemic of opioid overdose and the potential contribution...
Paper
Apr 01 2019
By: John Wood
About: Pain-in-a-Dish Expands the Nav1.7 Research Menu
In the accompanying paper, Bennett, Serra, and Tracey make an important...
News
Mar 29 2019
By: Howard Fields
About: Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.
Negus and colleagues have provided a useful in-depth review of the broad...
Paper
Mar 14 2019
By: Markus Ploner
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
The study by Tan et al. represents a major step forward in understanding...
Paper
Jan 17 2019
By: Howard Fields
About: Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.
This is an excellent paper investigating the analgesic effect of sucrose...
Paper
Nov 23 2018
By: Hiroshi Ueda
About: Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.
This study seems to provide the first clinical evidence to support basic...
Paper
Oct 05 2018
By: Halina Machelska
About: Kappa Opioid Receptor Distribution and Function in Primary Afferents.
This is an interesting study confirming analgesic effects mediated by...
Paper
Aug 20 2018
By: Ru-Rong Ji
About: MicroRNA-30c-5p modulates neuropathic pain in rodents.
This is an interesting study with translational potential. The authors...
Paper
Aug 13 2018
By: Seena Ajit
About: miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
The conventional role of microRNAs (miRNAs) is to regulate gene expression...
Paper
Jun 18 2018
By: PRF Executive Editor
About: NIH Announces HEAL Initiative to Combat Opioid Crisis
Since publication of this news story, JAMA has published a Viewpoint by...
News
May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
News
May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper
Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper
Mar 30 2018
By: Ru-Rong Ji
About: Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na1.6 in sensory neurons to promote neuropathic pain.
This is an interesting study that has demonstrated palmitoylation as a...
Paper
Mar 23 2018
By: Xinzhong Dong
About: Circuit dissection of the role of somatostatin in itch and pain.
This is a very interesting study from the labs of Andrew Todd and Mark...
Paper
Feb 12 2018
By: John Quintner
About: What's in a Name for Chronic Pain?
Dr. Clauw and his colleagues clearly favoured "centralized" as the third...
News
Feb 06 2018
By: Samuel Krimmel
About: Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
The medial frontal cortex (MFC) contains multiple regions under intense...
Paper
Jan 17 2018
By: Michael Costigan
About: Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Editor's note: This comment is co-authored by Rafael González-Cano and...
Paper
Dec 18 2017
By: Ru-Rong Ji
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
The Cell paper focused on the acute effects of the novel opioid agonists,...
Paper
Nov 26 2017
By: Howard Fields
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
This is a very thorough study that examines a group of structurally...
Paper
Nov 05 2017
By: Heather Rossi
About: Does the Location of Pain Matter?
Surprising that the tendency for co-morbidity of different conditions did...
Discussion
Nov 02 2017
By: Michael O'Leary
About: Q & A: A Question About Local Anesthetics
I agree, low pH associated with infection, injury or ischemia will favor...
Q & A
Oct 06 2017
By: Ted Price
About: Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
This comment is coauthored by Ted Price, Head of Neuroscience, UT Dallas;...
Paper

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.