News

Oct 15 2019
If at First You Don’t Succeed, Try, Try Again: An Improved Strategy to Treat Itch
Converging evidence from mouse models and human sensory neurons points to the spinal cord receptor NPR1 as a potential treatment target for itch
news Drug Development | Research
Oct 14 2019
Pain Nerve Endings: “Bare” No More
Nociceptive Schwann cells in the skin are an active player in pain sensation
news Research
Oct 02 2019
“Everybody Has Won and All Must Have Prizes”: Dodo Birds in Psychological Treatments for Chronic Pain
Do different psychological interventions that alleviate pain work through similar or unique mechanisms?
news Conferences | Research
Sep 24 2019
The Mouse Pain Scale: A More Reliable and Unbiased Way to Assess Animal Behavior in Pain Research
New approach uses high-speed videography, statistical modeling, and machine learning to identify pain- versus non-pain-related behaviors
news Research

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Community & Resource Updates

World Congress of Neurology 2019
26 Oct 2019 to 31 Oct 2019
Dubai, United Arab Emirates

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Assistant Professor - Pain Scientist
University of Toronto, Faculty of Dentistry
Toronto, Ontario, Canada

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Community Updates Lower block

Forums

Oct 09 2019
North American Pain School 2019: A Conversation With Visiting Faculty Member Cheryl Stucky
Andy Tay

Editor’s note: The fourth North...

Interview
Oct 07 2019
IASP Pain Research Forum Asia-Pacific Webinar: The Role of Mitochondrial Dysfunction in the Pathophysiology of Painful Diabetic Neuropathy
PRF Team

The IASP Pain Research Forum will host a webinar with Fumimasa Amaya, MD, PhD, Kyoto Prefectural University of Medicine, Japan,...

Webinar

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Recent Comments

Sep 30 2019
By: Mamata Tamrakar
About: A New Proposed Definition of Pain
The pain threshold for each individual differs, which makes it more...
News
Sep 30 2019
By: John Quintner
About: A New Proposed Definition of Pain
In his introductory remarks, although Murat Aydede1 mentions the...
News
Sep 30 2019
By: Marc Mathys
About: A Causal Role for Long-Term Potentiation in Chronic Pain
Wonderful paper. Have the researchers found any evidence for differences...
News
Sep 14 2019
By: Murat Aydede
About: A New Proposed Definition of Pain
The news article states: "But one thing most agree on is that the...
News
Jul 13 2019
By: Howard Fields
About: Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial.
In this elegant study, the authors compare lidocaine injection of the...
Paper
Jun 03 2019
By: Howard Fields
About: Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. Published May 9, 2019 by the US Department of Health.
Because of the epidemic of opioid overdose and the potential contribution...
Paper
Apr 01 2019
By: John Wood
About: Pain-in-a-Dish Expands the Nav1.7 Research Menu
In the accompanying paper, Bennett, Serra, and Tracey make an important...
News
Mar 29 2019
By: Howard Fields
About: Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.
Negus and colleagues have provided a useful in-depth review of the broad...
Paper
Mar 14 2019
By: Markus Ploner
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
The study by Tan et al. represents a major step forward in understanding...
Paper
Jan 17 2019
By: Howard Fields
About: Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.
This is an excellent paper investigating the analgesic effect of sucrose...
Paper
Nov 23 2018
By: Hiroshi Ueda
About: Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.
This study seems to provide the first clinical evidence to support basic...
Paper
Oct 05 2018
By: Halina Machelska
About: Kappa Opioid Receptor Distribution and Function in Primary Afferents.
This is an interesting study confirming analgesic effects mediated by...
Paper
Aug 20 2018
By: Ru-Rong Ji
About: MicroRNA-30c-5p modulates neuropathic pain in rodents.
This is an interesting study with translational potential. The authors...
Paper
Aug 13 2018
By: Seena Ajit
About: miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
The conventional role of microRNAs (miRNAs) is to regulate gene expression...
Paper
Jun 18 2018
By: PRF Executive Editor
About: NIH Announces HEAL Initiative to Combat Opioid Crisis
Since publication of this news story, JAMA has published a Viewpoint by...
News
May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
News
May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper
Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper
Mar 30 2018
By: Ru-Rong Ji
About: Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na1.6 in sensory neurons to promote neuropathic pain.
This is an interesting study that has demonstrated palmitoylation as a...
Paper
Mar 23 2018
By: Xinzhong Dong
About: Circuit dissection of the role of somatostatin in itch and pain.
This is a very interesting study from the labs of Andrew Todd and Mark...
Paper
Feb 12 2018
By: John Quintner
About: What's in a Name for Chronic Pain?
Dr. Clauw and his colleagues clearly favoured "centralized" as the third...
News
Feb 06 2018
By: Samuel Krimmel
About: Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
The medial frontal cortex (MFC) contains multiple regions under intense...
Paper
Jan 17 2018
By: Michael Costigan
About: Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Editor's note: This comment is co-authored by Rafael González-Cano and...
Paper

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