News

Jan 11 2022
Stunning Image of a Dorsal Root Ganglion Receives Honors From Nikon and Nature
The image, captured by Paula Diaz using fluorescence microscopy, was recognized as one of the best science images of 2021.
news People | Research
Jan 07 2022
How Does Pain Lead to a Decrease in Brain Dopamine Levels?
Incoming pain signals from the spinal cord reach the lateral parabrachial nucleus in the brainstem, and a subpopulation of its projection neurons acts to inhibit dopamine release from neurons in the midbrain.
news Research
Dec 23 2021
The Most Popular Content of PRF in 2021
A news story on the sex-specific differences in a pain mechanism, a paper exploring how spinal macrophages suppress pain hypersensitivity, and a seminar about a neurocultural model of pain led the pack.
news Drug Development | People | Research
Dec 17 2021
STING Immunotherapy: A Complementary Approach to Treating Bone Cancer Pain
Two studies indicate that activation of the pattern recognition receptor STING not only reduces bone tumor growth, but also reduces pain through complementary mechanisms
news Research

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Community & Resource Updates

2022 San Diego Pain Summit
22 Feb 2022 to 27 Feb 2022
Paradise Point Resort, 1404 Vacation Rd, San Diego, CA 92109
Registration Deadline:
20 Feb 2022

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Tenure-Track Assistant Professor
Saint Louis University Center for Neuroscience, Department of Pharmacology & Physiology
Saint Louis, Missouri, US

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Community Updates Lower block

Forums

Jan 18 2022
IASP Neuropathic Pain Special Interest Group Workshop: Neuropathic Pain and COVID-19
PRF Team

Senior manager’s note: Attendance is free for IASP members, though registration is still required. A registration fee of $25 is...

Webinar
Jan 14 2022
Challenging the Status Quo of Traditional Animal Pain Models and the Behavioral Correlates: An Interview With Anke Tappe-Theodor
Federica Franciosa

Anke Tappe-Theodor, PhD, is a habilitated scientist in the Faculty of Pharmacology at Ruprecht Karls University of Heidelberg, Germany. She...

Interview

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Recent Comments

Oct 26 2021
By: Matthew Sapio
About: The Pain Research Forum Welcomes Gregory Carbonetti and Thanks Neil Andrews for His Outstanding Service
Congratulations, Greg! Thanks for taking up the mantle. Good luck to Neil...
News
Sep 28 2021
By: John Quintner
About: A Neurobiological Perspective on Low Back Pain: An Interview With Ben Wand
Professor Wand, thank you for an interesting interview. Perhaps you would...
Interview
Sep 21 2021
By: Matthew Sapio
About: Cutaneous Pain in Disorders Affecting Peripheral Nerves.
This is a tour de force. I am reading it right now and I am really getting...
Paper
Aug 31 2021
By: Michael Iadarola
About: Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials.
Editor's note: Michael Iadarola is a co-author of the above journal...
Paper
Aug 13 2021
By: Bamidele Owoyele
About: The Naked Mole-Rat: A Curious Creature With Many Lessons for Pain Researchers
This is an interesting piece. One is amazed at this kind of diversity in...
News
Jul 23 2021
By: George Naratadam
About: TRP Channels and Mechanical Pain: Starring TRPC5!
Something to note: TRPC channels (and TRPC5 in particular) have been...
News
May 26 2021
By: Fanglin Lu
About: I Feel Your Pain – and Analgesia
So does it mean that there might be a confounding factor in all pain...
News
Feb 20 2021
By: Pierrick Poisbeau
About: Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
It's fascinating to discover that only few astrocytes in the amygdala are...
Paper
Feb 03 2021
By: Andrew Wright
About: The Pain Beat (Episode 5) – The Coding of Sensory Information: Population Coding or Labeled Lines?
Thank you. I very much enjoyed the podcast; it was interesting and...
Interview
Aug 15 2020
By: John Quintner
About: A New Proposed Definition of Pain
Professor Harold Merskey, who was the chair of the original IASP...
News
Aug 12 2020
By: Eric Visser
About: A New Proposed Definition of Pain
Modified pain definition: An unpleasant sensory and emotional experience...
News
Jul 23 2020
By: John Quintner
About: A New Proposed Definition of Pain
Introducing the word "resembling" in relation to "the unpleasant sensory...
News
Jul 16 2020
By: PRF Executive Editor
About: A New Proposed Definition of Pain
The revised definition of pain has now been published in PAIN, along with...
News
May 15 2020
By: Johan Vlaeyen
About: Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
You may wish to have a look at some more recent updates of this paper: [1...
Paper
Mar 06 2020
By: Ashlie Reker
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
Editor's note: this comment is co-authored by Ashlie Reker and Steve...
Paper
Feb 24 2020
By: Steve Negus
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
An unexpected finding in this study was that CCI increased rather than...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Editor's note: This was the most popular paper on PRF over the past...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
Editor's Note: This paper was the most popular paper on PRF in 2019....
Paper
Sep 30 2019
By: Mamata Tamrakar
About: A New Proposed Definition of Pain
The pain threshold for each individual differs, which makes it more...
News
Sep 30 2019
By: John Quintner
About: A New Proposed Definition of Pain
In his introductory remarks, although Murat Aydede1 mentions the...
News
Sep 30 2019
By: Marc Mathys
About: A Causal Role for Long-Term Potentiation in Chronic Pain
Wonderful paper. Have the researchers found any evidence for differences...
News
Sep 14 2019
By: Murat Aydede
About: A New Proposed Definition of Pain
The news article states: "But one thing most agree on is that the...
News
Jul 13 2019
By: Howard Fields
About: Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial.
In this elegant study, the authors compare lidocaine injection of the...
Paper
Jun 03 2019
By: Howard Fields
About: Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. Published May 9, 2019 by the US Department of Health.
Because of the epidemic of opioid overdose and the potential contribution...
Paper
Apr 01 2019
By: John Wood
About: Pain-in-a-Dish Expands the Nav1.7 Research Menu
In the accompanying paper, Bennett, Serra, and Tracey make an important...
News

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