News

Jun 24 2020
A 10-Year Anniversary: Reflecting on the Declaration of Montreal
One decade ago, pain stakeholders from around the globe called for the world to recognize that access to pain management is a fundamental human right. How has the Declaration of Montreal influenced pain research and treatment in the years since?
news Research
Jun 18 2020
Does Dendritic Spine Plasticity Contribute to Pain? The Evidence Is Mushrooming
Two-photon imaging study links changes in the structure of dorsal horn dendritic spines to neuropathic pain, in a mouse spared nerve injury model
news Drug Development | Research
Jun 10 2020
When Mice Make Faces, Machine Learning to the Rescue!
Algorithm identifies and classifies characteristic expressions in response to emotional events; calcium imaging reveals neuronal underpinnings
news Research
Jun 03 2020
A Paradox of Thermosensation in Mice: Perceiving Warmth Requires a Cool-Activated Channel
The menthol receptor TRPM8 is necessary for mice to perceive very small skin temperature increases as warming; results support pattern theory of thermosensation
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news Research

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Faculty of Dentistry University of Toronto and Child Health Evaluative Services SickKids
Toronto, Ontario, Canada

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Jul 09 2020
Looking to Toxins to Understand Pain: A Chat With Australian Pain Society 2020 Rising Star Samuel Robinson
Lincoln Tracy

Samuel Robinson, PhD, is a postdoctoral research fellow at the Institute for Molecular Bioscience, University of Queensland, Australia. He...

Interview
Jul 06 2020
PRF Seminar – Pain Programs at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS): The Preclinical Screening Platform for Pain (PSPP) and the Early Phase Pain Investigation Clinical Network (EPPIC-Net)
PRF Team

Editor’s note: This is the 10th in a series of weekly PRF seminars designed to help keep the pain research community connected during...

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Recent Comments

May 15 2020
By: Johan Vlaeyen
About: Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
You may wish to have a look at some more recent updates of this paper: [1...
Paper
Mar 06 2020
By: Ashlie Reker
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
Editor's note: this comment is co-authored by Ashlie Reker and Steve...
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Feb 24 2020
By: Steve Negus
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
An unexpected finding in this study was that CCI increased rather than...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Editor's note: This was the most popular paper on PRF over the past...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
Editor's Note: This paper was the most popular paper on PRF in 2019....
Paper
Sep 30 2019
By: Mamata Tamrakar
About: A New Proposed Definition of Pain
The pain threshold for each individual differs, which makes it more...
News
Sep 30 2019
By: John Quintner
About: A New Proposed Definition of Pain
In his introductory remarks, although Murat Aydede1 mentions the...
News
Sep 30 2019
By: Marc Mathys
About: A Causal Role for Long-Term Potentiation in Chronic Pain
Wonderful paper. Have the researchers found any evidence for differences...
News
Sep 14 2019
By: Murat Aydede
About: A New Proposed Definition of Pain
The news article states: "But one thing most agree on is that the...
News
Jul 13 2019
By: Howard Fields
About: Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial.
In this elegant study, the authors compare lidocaine injection of the...
Paper
Jun 03 2019
By: Howard Fields
About: Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. Published May 9, 2019 by the US Department of Health.
Because of the epidemic of opioid overdose and the potential contribution...
Paper
Apr 01 2019
By: John Wood
About: Pain-in-a-Dish Expands the Nav1.7 Research Menu
In the accompanying paper, Bennett, Serra, and Tracey make an important...
News
Mar 29 2019
By: Howard Fields
About: Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.
Negus and colleagues have provided a useful in-depth review of the broad...
Paper
Mar 14 2019
By: Markus Ploner
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
The study by Tan et al. represents a major step forward in understanding...
Paper
Jan 17 2019
By: Howard Fields
About: Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.
This is an excellent paper investigating the analgesic effect of sucrose...
Paper
Nov 23 2018
By: Hiroshi Ueda
About: Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.
This study seems to provide the first clinical evidence to support basic...
Paper
Oct 05 2018
By: Halina Machelska
About: Kappa Opioid Receptor Distribution and Function in Primary Afferents.
This is an interesting study confirming analgesic effects mediated by...
Paper
Aug 20 2018
By: Ru-Rong Ji
About: MicroRNA-30c-5p modulates neuropathic pain in rodents.
This is an interesting study with translational potential. The authors...
Paper
Aug 13 2018
By: Seena Ajit
About: miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
The conventional role of microRNAs (miRNAs) is to regulate gene expression...
Paper
Jun 18 2018
By: PRF Executive Editor
About: NIH Announces HEAL Initiative to Combat Opioid Crisis
Since publication of this news story, JAMA has published a Viewpoint by...
News
May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
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May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper
Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper

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