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Pain Gene Resource

Page Gene Resource

Select to Compare Symbol Gene Name Chr. Chr. Location Function Phenotype/Disease Number of Studiessort descending
IL13 interleukin 13 5 131,993,864: 131,996,800 anti-inflammatory cytokine breast pain in women with breast cancer 1
IL16 interleukin 16 (lymphocyte chemoattractant factor) 15 81,489,219: 81,605,101 stimulates migratory response in inflammatory cells 1
ATL1 atlastin GTPase 1 14 50,069,550: 50,169,534 endoplasmic reticulum GTP-binding protein Hereditary Sensory and Autonomic Neuropathy Type ID 1
KCNK18 potassium channel, subfamily K, member 18 10 118,957,000: 118,969,809 two-pore domain (K2P) potassium channel familial migraine with aura 1
CCT5 chaperonin-containing TCP1, subunit 5 (epsilon) 5 10,250,282: 10,266,500 molecular chaperone sensory neuropathy 1
KCNS1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Kv9.1 20 43720951: 43729753 voltage-gated potassium channel subunit pain after nerve injury, experimental pain sensitivity 1
CACNA2D3 voltage-dependent calcium channel, α2δ subunit 3 3 54,156,693: 55,108,582 regulates voltage-dependent calcium channels experimental thermal pain, chronic back pain 1
CACNG2 voltage-dependent calcium channel, γ subunit 2 22 36,960,104: 37,098,90 voltage-dependent calcium channel subunit chronic pain following nerve injury 1
MAOB monoamine oxidase B X 43,625,858: 43,741,721 catalyze the oxidation and degradation of monoamine neurotransmitters acute postsurgical pain 1
DNMT1 DNA (cytosine-5-)-methyltransferase-1 19 10,244,023:10,305,755 controls gene expression through DNA methylation Hereditary sensory and autonomic neuropathy type I with dementia and hearing loss (HSAN IE) 1
KIF1A kinesin family member 1A 2 241,653,181: 241,759,725 motor for axonal transport of synaptic vesicles Hereditary Sensory and Autonomic Neuropathy Type IIC (HSN2C) 1
IL1R1 interleukin 1 receptor, type I 2 102,686,835: 102,796,333 cytokine receptor for interleukin 1 breast pain in women with breast cancer 1
IL1R2 interleukin 1 receptor, type II 2 102,608,305: 102,644,884  cytokine receptor for interleukin 1 postsurgical pain 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 14 77,973,272: 78,083,110 a subunit of a key enzyme in sphingolipid biosynthesis Hereditary Sensory and Autonomic Neuropathy Type IC (HSAN1C) 2
ADRA2C α2C adrenergic receptor 4 3,768,296: 3,770,251 adrenergic signaling angina, cold pain sensitivity 2
SCN10A sodium channel, voltage-gated, type X, alpha subunit 3 38,738,836: 38,835,500 voltage-gated sodium channel Nav1.8 subunit familial episodic pain 2 (FEPS2) 2
IL1A interleukin 1, alpha 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain 2
FAAH fatty acid amide hydrolase 1 46,859,939: 46,879,520 inactivates the endocannabinoid anandamide experimental cold pain, functional GI disorders, Parkinson disease 3
FAM134B family with sequence similarity 134, member B 5 16,473,148: 16,617,118 Required for long-term survival of nociceptive and autonomic ganglion neurons Hereditary Sensory and Autonomic Neuropathy Type IIB (HSAN2B) 3
MEFV Familal Mediterranean fever gene 16 3,292,028: 3,306,627 modulator of innate immunity fibromyalgia, dysmenorrhea 3
SCN11A sodium channel, voltage-gated, type XI, alpha subunit 3 38,887,259: 38,995,135 voltage-gated sodium channel Nav1.9 subunit congenital insensitivity to pain; familial episodic pain; small fiber neuropathy 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 9 111,629,801: 111,696,608 scaffold protein and regulator of proinflammatory signaling Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia 3
IL8 interleukin 8 4 74,606,275: 74,609,431 proinflammatory cytokine cancer pain, temporomandibular disorder 4
KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 21 38,996,786: 39,288,696 potassium channel that regulates insulin secretion by glucose and neurotransmitters postoperative analgesic use, breast cancer pain, chronic pain, methadone use 4
TRPA1 transient receptor potential cation channel, subfamily A, member 1 8 72,933,487: 72,987,819 nonselective cation channel that senses environmental irritants Familial episodic pain syndrome, somatosensory function 4
NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory and Autonomic Neuropathy type V, HSAN5) 5
IL1B interleukin 1, beta 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain, burning mouth syndrome, migraine, vulvar vestibulitis 5
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 16 89,984,287: 89,987,385 controls melanogenesis pain and analgesia, fear of dental pain, vuvlar vestibulitis 6
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
ADRB2 β2-adrenergic receptor 5 148,206,156: 148,208,188 adrenergic signaling TMD, angina, fibromyalgia, chronic widespread pain 7
IL1RN interleukin 1 receptor antagonist 2 113,885,138: 113,891,592 inhibits the activity of IL-1 postoperative opioid use, lower back pain, vulvar vestibulitis 8
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5 1,392,910: 1,445,538 dopamine transporter experimental cold pain 9
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 9 94,793,427: 94,877,690 a subunit of a key enzyme in sphingolipid biosynthesis Hereditary Sensory and Autonomic Neuropathy Type IA (HSAN1A) 10
IL10 Interleukin 10 4 74,606,275: 74,609,431 inhibits the synthesis of a number of cytokines postsurgical pain; irritable bowel syndrome; pelvic pain, diabetic peripheral neuropathy 10
WNK1 WNK lysine deficient protein kinase 1 12 862,225: 1,020,617 kinase; regulates ion transport Hereditary Sensory and Autonomic Neuropathy Type IIA (HSAN2A), cold pain sensitivity 12
MAOA monoamine oxidase A X 43,515,409: 43,606,067 catalyzes the oxidation and degradation of monoamine neurotransmitters postoperative pain, cold pain tolerance, migraine 12
ESR1 estrogen receptor 1 6 152,128,454: 152,424,406 nuclear estrogen receptor migraine, dysmenorrhea, osteoarthritis pain 13
GCH1 GTP cyclohydrolase 1 14 55,308,724: 55,369,542 rate-limiting enzyme for BH4 synthesis acute and chronic pain, experimental pain 13
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13 47,407,513: 47,470,369 receptor for the neurotransmitter serotonin musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other 13
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1 156,830,671: 156,851,642 receptor tyrosine kinase for nerve growth factor congenital insensitivity to pain with anhidrosis (CIPA); hereditary and sensory autonomic neuropathy type IV (HSAN4) 18
CACNA1A P/Q-type voltage gated calcium channel, α1a subunit 19 13,317,256: 13,617,274 P/Q-type calcium channel subunit migraine 24
ATP1A2 Na+/K+ ATPase, α2 subunit 1 160,085,520: 160,113,372 Na+/K+ ATPase catalytic subunit migraine 35
SCN9A sodium channel, voltage-gated, type IX, alpha subunit 2 167,051,704: 167,232,497 voltage-gated sodium channel Nav1.7 subunit erythermalgia, PEPD, CIP, pain sensitivity 47
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