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Pain Gene Resource

Page Gene Resource

Select to Compare Symbol Gene Name Chr. Chr. Location Function Phenotype/Disease Number of Studiessort descending
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5 1,392,910: 1,445,538 dopamine transporter experimental cold pain 9
MAOA monoamine oxidase A X 43,515,409: 43,606,067 catalyzes the oxidation and degradation of monoamine neurotransmitters postoperative pain, cold pain tolerance, migraine 12
ESR1 estrogen receptor 1 6 152,128,454: 152,424,406 nuclear estrogen receptor migraine, dysmenorrhea, osteoarthritis pain 13
GCH1 GTP cyclohydrolase 1 14 55,308,724: 55,369,542 rate-limiting enzyme for BH4 synthesis acute and chronic pain, experimental pain 13
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13 47,407,513: 47,470,369 receptor for the neurotransmitter serotonin musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other 13
CACNA1A P/Q-type voltage gated calcium channel, α1a subunit 19 13,317,256: 13,617,274 P/Q-type calcium channel subunit migraine 24
ATP1A2 Na+/K+ ATPase, α2 subunit 1 160,085,520: 160,113,372 Na+/K+ ATPase catalytic subunit migraine 35
SCN9A sodium channel, voltage-gated, type IX, alpha subunit 2 167,051,704: 167,232,497 voltage-gated sodium channel Nav1.7 subunit erythermalgia, PEPD, CIP, pain sensitivity 46