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Pain Gene Resource

Page Gene Resource

Select to Compare Symbol Gene Name Chr. Chr. Location Function Phenotype/Disease Number of Studiessort descending
SCN11A sodium channel, voltage-gated, type XI, alpha subunit 3 38,887,259: 38,995,135 voltage-gated sodium channel Nav1.9 subunit congenital insensitivity to pain; familial episodic pain; small fiber neuropathy 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 9 111,629,801: 111,696,608 scaffold protein and regulator of proinflammatory signaling Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia 3
TRPA1 transient receptor potential cation channel, subfamily A, member 1 8 72,933,487: 72,987,819 nonselective cation channel that senses environmental irritants Familial episodic pain syndrome, somatosensory function 4
IL8 interleukin 8 4 74,606,275: 74,609,431 proinflammatory cytokine cancer pain, temporomandibular disorder 4
KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 21 38,996,786: 39,288,696 potassium channel that regulates insulin secretion by glucose and neurotransmitters postoperative analgesic use, breast cancer pain, chronic pain, methadone use 4
IL1B interleukin 1, beta 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain, burning mouth syndrome, migraine, vulvar vestibulitis 5
NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory and Autonomic Neuropathy type V, HSAN5) 5
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 16 89,984,287: 89,987,385 controls melanogenesis pain and analgesia, fear of dental pain, vuvlar vestibulitis 6
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
ADRB2 β2-adrenergic receptor 5 148,206,156: 148,208,188 adrenergic signaling TMD, angina, fibromyalgia, chronic widespread pain 7