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Pain Gene Resource

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Select to Compare Symbol Gene Name Chr.sort descending Chr. Location Function Phenotype/Disease Number of Studies
FAM134B family with sequence similarity 134, member B 5 16,473,148: 16,617,118 Required for long-term survival of nociceptive and autonomic ganglion neurons Hereditary Sensory and Autonomic Neuropathy Type IIB (HSAN2B) 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5 1,392,910: 1,445,538 dopamine transporter experimental cold pain 9
ESR1 estrogen receptor 1 6 152,128,454: 152,424,406 nuclear estrogen receptor migraine, dysmenorrhea, osteoarthritis pain 13
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 9 111,629,801: 111,696,608 scaffold protein and regulator of proinflammatory signaling Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia 3
KCNK18 potassium channel, subfamily K, member 18 10 118,957,000: 118,969,809 two-pore domain (K2P) potassium channel familial migraine with aura 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13 47,407,513: 47,470,369 receptor for the neurotransmitter serotonin musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other 13
ATL1 atlastin GTPase 1 14 50,069,550: 50,169,534 endoplasmic reticulum GTP-binding protein Hereditary Sensory and Autonomic Neuropathy Type ID 1
GCH1 GTP cyclohydrolase 1 14 55,308,724: 55,369,542 rate-limiting enzyme for BH4 synthesis acute and chronic pain, experimental pain 13
CACNA1A P/Q-type voltage gated calcium channel, α1a subunit 19 13,317,256: 13,617,274 P/Q-type calcium channel subunit migraine 24

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