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Pain Gene Resource

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Select to Compare Symbol Gene Name Chr. Chr. Location Function Phenotype/Disease Number of Studies
FAAH fatty acid amide hydrolase 1 46,859,939: 46,879,520 inactivates the endocannabinoid anandamide experimental cold pain, functional GI disorders, Parkinson disease 3
FAM134B family with sequence similarity 134, member B 5 16,473,148: 16,617,118 Required for long-term survival of nociceptive and autonomic ganglion neurons Hereditary Sensory and Autonomic Neuropathy Type IIB (HSAN2B) 3
GCH1 GTP cyclohydrolase 1 14 55,308,724: 55,369,542 rate-limiting enzyme for BH4 synthesis acute and chronic pain, experimental pain 13
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13 47,407,513: 47,470,369 receptor for the neurotransmitter serotonin musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other 13
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 9 111,629,801: 111,696,608 scaffold protein and regulator of proinflammatory signaling Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia 3
IL1A interleukin 1, alpha 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain 2
IL1B interleukin 1, beta 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain, burning mouth syndrome, migraine, vulvar vestibulitis 5
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
IL8 interleukin 8 4 74,606,275: 74,609,431 proinflammatory cytokine cancer pain, temporomandibular disorder 4
KCNK18 potassium channel, subfamily K, member 18 10 118,957,000: 118,969,809 two-pore domain (K2P) potassium channel familial migraine with aura 1

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