Pain Research Forum

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    You can sign up to receive an email when the Papers of the Week, News stories, or other new content is posted on the PRF. Just click "Subscriptions" in the left column of your Member Profile. Not a member? Join today!

  • Divide and Conquer?

    Blocking the interaction between TRPV1 and the scaffolding protein AKAP79 may offer a novel way to modulate channel activity and reduce pain.
    Read more...

  • Register Now for June Webinar

    Andrew S.C. Rice, Imperial College London, UK, and a distinguished panel are set to discuss animal models used in neuropathic pain studies. Sign up now for this June 27, 2013 webinar. Read more...

  • New Avenues in Itch

    In three recent papers, researchers describe a novel therapeutic strategy, reveal a role for TRPA1 in chronic itch, and discover a new itch neurotransmitter. Read more...

  • Catching Up with Young Investigators Honored at APS 2013

    PRF spoke with three award-winning researchers recognized at the recent American Pain Society conference in New Orleans. Read our interviews with Rebecca Seal, Reza Sharif-Naeini, and Laura Simons...

News

Jun 17 2013
VGLUT3: First a Role in Hearing, Then a Part in Pain
A conversation with Rebecca Seal, a recipient of a 2013 Rita Allen Foundation Award in Pain research grant from the Rita Allen Foundation and American Pain Society
news Conferences | People | Research
Jun 17 2013
Elucidating a Role for Inhibitory Interneurons in Neuropathic Pain
A conversation with Reza Sharif-Naeini, a recipient of a 2013 Rita Allen Foundation Award in Pain research grant from the Rita Allen Foundation and the American Pain Society
news Conferences | People | Research
Jun 10 2013
Progress Toward Understanding and Treating Itch
Silencing itch-transducing neurons, a role for TRPA1 in chronic itch, and a new itch neurotransmitter
news Research
Jun 04 2013
Peptides Hit Soft Spot for TRPV1 Sensitization
Potential target for inflammatory hyperalgesia exposed
news Research

Papers of the Week

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Community & Resource Updates

Alan Edwards Fellowship in Clinical Pain Research
The Louise and Alan Edwards Foundation
Start date:
1 Jul 2013

See all Funding Opportunities

Two-year postdoctoral position
King's College London
London, UK

See all Jobs

Community Updates Lower block

Forums

Jun 03 2013
Lost in Translation: Improving the Validity of Animal Models Used in the Study of Neuropathic Pain
PRF Editors

Andrew S.C. Rice, Imperial College London and Chelsea and Westminster Hospital, NHS Foundation Trust, UK, will present...

webinar
May 20 2013
Webinar and Live Discussion: Measuring the Affective Dimensions of Pain in Animal Models
PRF Editors

Editors' note: The May 15th webinar with speaker Frank Porreca is now available for viewing. Access the presentation and panel...

2 Members Recommend
webinar

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Recent Comments

Jun 16 2013
By: Mathieu Roy
About: A Brain Signature for Physical Pain?
This comment was coauthored by Tor D. Wager, Lauren Y. Atlas, Martin A....
News
May 20 2013
By: Daniel I. Chasman
About: News Brief: Sleep-Disrupting Gene Mutation Implicated in Migraine
Heterogeneity of clinical characteristics has challenged an understanding...
News
May 15 2013
By: Markus Schuerks
About: News Brief: Sleep-Disrupting Gene Mutation Implicated in Migraine
Brennan et al. describe two mutations in the casein kinase I δ (CKIδ) gene...
News
May 08 2013
By: Marshall Devor
About: A Brain Signature for Physical Pain?
This article makes the radical claim that an objective, neurologic...
News
May 07 2013
By: Massieh Moayedi
About: A Brain Signature for Physical Pain?
This comment was coauthored by David Seminowicz, University of Maryland,...
News
May 06 2013
By: William Schmidt
About: Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.
To my knowledge, this is the first Phase 3 study to show a statistically...
Paper
Apr 25 2013
By: Ru-Rong Ji
About: WNT signaling underlies the pathogenesis of neuropathic pain in rodents.
This is an interesting paper, which demonstrates a role for the Wnt...
Paper
Apr 20 2013
By: Maral Tajerian
About: Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex.
Curious about which particular genes are affected? Follow up paper now...
Paper
Apr 16 2013
By: Joseph Martin
About: A New Cause for Unexplained Pain in Children
This is a seminal advance in our appreciation of an under-recognized...
News
Apr 15 2013
By: Magdalene Moran
About: Watching Pain Become Chronic
This paper highlights the importance of understanding disease progression...
News
Apr 15 2013
By: Pankaj Pasricha
About: Watching Pain Become Chronic
This is an important study from a very distinguished group studying...
News
Mar 21 2013
By: Emmanuel Deval
About: Serotonin Facilitates Peripheral Pain Sensitivity in a Manner That Depends on the Nonproton Ligand Sensing Domain of ASIC3 Channel.
Wang and colleagues report here the interesting observation that the...
Paper
Mar 15 2013
By: Ted Price
About: Benzoquinone Reveals a Cysteine-dependent Desensitization Mechanism of TRPA1.
This is a fascinating new finding concerning the pharmacology of TRPA1....
Paper
Mar 11 2013
By: Sid Simon
About: Unraveling the Mysteries of TRPV1 Regulation
The Regulation of TRPV1 by Phosphoinositides in Liposomes This comment is...
News
Feb 18 2013
By: James Campbell
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Acute opioids are expected to have different side effects compared to...
Discussion
Feb 18 2013
By: James Rybacki
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
I've always included a caution in my Essential Guide to Prescription Drugs...
Discussion
Feb 18 2013
By: Xian-Guo Liu
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
It has been shown that many patients with chronic pain have cognitive...
Discussion
Feb 12 2013
By: Karen Berkley
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
This issue of the complex factors affecting car crash risk (“accident” is...
Discussion
Feb 12 2013
By: Miroslav "Misha" Backonja
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
We answered this question in the early 1990s. We did a morphine placebo-...
Discussion
Feb 12 2013
By: Mark Wallace
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
There was a study in the late 1990s (see attached slides below on earlier...
Discussion
Feb 12 2013
By: Jordan Karp
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
The study design could be the comparison of rates of accidents from home...
Discussion
Feb 12 2013
By: Harry Gould
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Karen's question is a very important one, and well worth discussing....
Discussion
Feb 12 2013
By: Karen Berkley
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Has anyone ever looked to see how the presence of pain, particularly...
Discussion
Jan 22 2013
By: Gil Yosipovitch
About: Found: A Home for Itch in Peripheral Neurons
This comment was coauthored by Leigh Nattkemper. Han et al. have provided...
News
Jan 17 2013
By: Mark Hutchinson
About: A New Pathway for Paradoxical Pain
This is a large body of work that very nicely characterizes a beautiful...
News

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our collection of topical articles on important issues in pain research--check out our inaugural articles on modeling pain in lower organisms and the role of glia in chronic pain. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes--you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.