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Pressure-point Pain and Lack of Response To It

by Donald Dalley on 3 May 2012

I have practiced martial arts now for more than 11 years and would like to understand why I don't feel some pain associated with the techniques applied to so…

Discussion

Last comment: Donald Dalley, 18 May 2012

There are a number of factors that may affect my nerve responses.

- C fibres are unmyelinated causing a slow response

- Remak bundle conditions, although my change in age doesn't seem… more

Moving Safer, More Effective Pain Medicines to Market: A Conversation with William Schmidt

by PRF Editors on 18 May 2012

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William Schmidt is an independent consultant to drug companies and emerging biotech companies around the world, helping to design clinical trials of new analgesic compounds. He also heads clinical…

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What Is the Reason for Lack of Translation in the Pain Field?

by Jeffrey Mogil on 28 Mar 2011

EDITOR'S NOTE: For this Inaugural Forum, Jeffrey Mogil of McGill University raises the question why have the fruits of basic research in the pain field not translated into new…

Discussion

Last comment: Mary Hannaman, 17 May 2012

A deepening chasm separates the knowledge obtained from a physician touching a patient with persistent pain and the expression of this knowledge in an animal model.

This division exists since… more

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Revealing the Inner Workings of Pain: A Conversation with Clifford Woolf

by PRF Editors on 11 May 2012

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Clifford Woolf, MB, BCh, PhD focuses on the basic mechanisms of pain, and translating discoveries into new therapeutics and diagnostics. He is best known for the discovery of central…

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Pain In Parkinson's Disease: Is Neurodegeneration in Peripheral Nerves to Blame?

by Joseph Martin on 6 Apr 2011

Neurologists have by tradition separated disorders of the central nervous system from those affecting the peripheral nervous system. Arguments for this distinction have noted the role of the blood-brain-barrier…

Discussion

Last comment: Kenneth Casey, 7 May 2012

The hypothesis offered by Reichling and Levine is interesting and provocative. However, the peripheral abnormalities they cite seem likely to be of marginal clinical significance for the chronic pain… more

Specificity Versus Patterning Theory: Continuing the Debate

by Allan Basbaum on 24 Jun 2011

Does the brain process and interpret innocuous and noxious stimuli by “reading” a pattern of activity across multimodal lines of activity, or are there specific, labeled lines that carry…

Discussion

Last comment: Kenneth Casey, 5 May 2012

Ghosts of Pattern and Specificity

This discussion by Alan Basbaum and Clifford Woolf deserves more attention than it has received, at least as judged by the number of commentaries. Conceptual… more

Easing Pain the World Over: A Conversation with Kathleen Foley

by PRF Editors on 4 May 2012

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Kathleen Foley, MD, has been caring for patients with cancer pain for over 40 years. Since 1974, she has been an attending neurologist at Memorial Sloan-Kettering Cancer Center in…

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Neuroscience 2011: A Student’s Eye View

by Shan Lou on 27 Jan 2012

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EDITOR'S NOTE: Shan Lou is a graduate student in the lab of Quifu Ma, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, where she studies the development of…

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“Redundancy” of Endocannabinoid Inactivation in Pain Control: What Do We Make of It?

by Vincenzo Di Marzo on 6 Dec 2011

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EDITOR’S NOTE: In this analysis, Vincenzo Di Marzo discusses recent developments in understanding endocannabinoid actions and metabolism, and efforts to target these lipid mediators as a novel approach to…

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Diabetic Neuropathic Pain Models

by Savithri Shivakumar on 3 Nov 2011

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Diabetic neuropathic pain is mainly seen in Type II diabetes in the clinical situation. However, the model widely used is the streptozotocin (STZ)-induced diabetic neuropathy model in rats. Is there…

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Pain Research Forum

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Pressure-point Pain and Lack of Response To It

Moving Safer, More Effective Pain Medicines to Market: A Conversation with William Schmidt

What Is the Reason for Lack of Translation in the Pain Field?

Revealing the Inner Workings of Pain: A Conversation with Clifford Woolf

Pain In Parkinson's Disease: Is Neurodegeneration in Peripheral Nerves to Blame?

Specificity Versus Patterning Theory: Continuing the Debate

Easing Pain the World Over: A Conversation with Kathleen Foley

Neuroscience 2011: A Student’s Eye View

“Redundancy” of Endocannabinoid Inactivation in Pain Control: What Do We Make of It?

Diabetic Neuropathic Pain Models

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